# Signal Detection Using EVDAS Data

Signal can support _Product-Event Combinations_ (PECs) from the EudraVigilance Data Analysis System (EVDAS), an EMA regulatory database.

EMA provides data in the following formats available for download from the EVDAS portal:
* Electronic Monitoring Reports (eRMRs): This report includes statistical scores and report counts, for example, the total number of serious _Cases_.
* Line Listings: This table accompanies the eRMR and is a list of Individual Case Safety Reports (ICSRs) that contributed to the _Case_ counts and statistical scores in the eRMR. Information also includes other important values, such as adverse event reactions and the _Worldwide UID_ (WWUID), to help identify _Cases_.

Your Admin loads the EVDAS eRMRs and line listings into Safety for signal detection in Signal.

## Prerequisites
Consider the following prerequisites:
* Before you can perform signal analysis on EVDAS data in Signal, your Admin must <a href="/en/gr/795474/">enable EVDAS data import</a> and <a href="/en/gr/773463/">prepare EVDAS data</a> for signal detection.
* To perform signal detection on EVDAS data in the same PEC with other supported data sources, your Admin must <a href="/en/gr/1005912/">enable Multi-Source Signal Data Consolidation</a>.

## How Vault Links the EVDAS Line Listings to a Safety Case

After your Admin loads the EVDAS eRMRs and line listings into Safety, Vault attempts to link each line listing case to a _Case_ version in Safety using the _WWUID_. The following scenarios occur depending on the matching parameters:

### WWUID Matches a Single Case in Safety

If the EVDAS Line Listing _WWUID_ matches a single _Case_, Vault sets the latest related _Case Version_ and _Case Number_ fields on the _EVDAS Line Listing_ record.

### WWUID Matches Multiple Cases in Safety

If the EVDAS Line Listing _WWUID_ matches multiple _Cases_ with different _Case_ numbers, Vault chooses the latest _Case_ version based on the _Case_ record with the most recent creation date. Vault then sets the latest related _Case Version_ and _Case Number_ fields on the _EVDAS Line Listing_ record.

### WWUID Does Not Match

If the EVDAS Line Listing _WWUID_ does not match any _Case_ records, Vault does not link the _EVDAS Line Listing_ case to any _Case_ in Safety.

## Next Steps: Create Safety Investigations from EVDAS eRMR Records

For _Product-Event Combinations_ (PECs) that require further investigation, you can <a href="/en/gr/752958/#create-a-safety-investigation-from-evdas-ermr-data">create a _Safety Investigation_</a> from the _EVDAS eRMR_ record.