) option to the _Inbox Item to Case Compare_ page during _Inbox Item_ promotion. When users select this option when promoting an _Inbox Item_, Vault generates a new _Case_ populated with the patient's details.
### Document Highlighter {#highlighter}
* **Enable Intake Document Highlighter**: Allows users to access the _Document Intake Highlighter_ panel.
* **Load Terms for Auto-Extraction**: Allows Vault to reference _Product_ data in your Vault when users run the _Extract Company Products_ action. To use this setting, you must select the _Enable Intake Document Highlighter_ checkbox.
### Follow-Up Options {#follow-up-options}
* **Allow follow-up with any matching UID**: Enables users to promote _Inbox Items_ when the Worldwide UID (_WWUID_) does not match but does match another UID, such as an _External System UID_ or a _Case Identifier_. For example, the _WWUID_ of an _Inbox Item_ does not match the _WWUID_ on the initial _Case_, but the _Case Identifier_ of the _Inbox Item_ matches the _WWUID_ of the initial _Case_. If the _Inbox Item_ contains a _WWUID_ value but the matching _Case_ does not, Vault maps the _WWUID_ value to the _Case_ upon promoting it to follow-up.
* **Prohibited States**: Prevents combining _Cases_ in specified lifecycle states with _Inbox Items_ to create _Follow-up Cases_ from the _Inbox Item to Case Compare_ page.
* **Allow "Ignore All" from specific Origins**: Allows users to ignore all follow-up information from the specified _Organizations_ on the _Inbox Item to Case Compare_ page. After you select the checkbox, you can select the applicable _Organizations_.
### Allow Merge Into Active Case {#merge}
* **Merge to Active Case Version**: Adds the _Merge to Current_ (
) option on the _Inbox Item to Case Compare_ page during _Inbox Item_ promotion.
* **Prohibited States**: Prevents merging _Inbox Items_ into _Cases_ in specified lifecycle states from the _Inbox Item to Case Compare_ page.
* **Require user performing merge to have edit access to target case**: Restricts the _Merge to Current_ action to users with _Edit_ access on the applicable target in-flight _Case_.
### Allow Mark Follow-up {#mark-follow-up}
* **Allow Mark Follow-up**: Adds the _Mark as Follow Up_ option to the _Inbox Item to Case Compare_ page during _Inbox Item_ promotion.
* **Prohibited States**: Prevents linking _Cases_ in specified lifecycle states to _Inbox Items_.
## ICSR Reporting Settings {#icsr}
Manage the _ICSR Reporting Settings_ in your Vault:
### Submissions {#submissions}
* **Cancel Auto-Submit for Translations**: Prevents auto-submissions for _Cases_ with unapproved _Localized Cases_.
* **Suppress File Generation for Auto-Submit Transmissions**: Prevents Vault from generating the Auto-Submission document before the initial document. Contact Veeva Managed Services to determine whether you should enable this setting.
* **Substitute Product/Study for Cross Reporting**: Specify how Vault evaluates the _Product_, _Product Family_, and _Study_ reporting rule parameters during cross reporting.
* **Logically Delete Non-Submittable Transmissions on Subsequent Evaluations**: Supports the logical deletion of non-submittable _Transmissions_ after the Safety reporting rule engine re-evaluates reporting obligations on updated _Cases_.
* **One Last Time Reporting for all Destinations**: Configures One Last Time (OLT) reporting logic for all reporting destinations with _Transmissions_ in the selected states, regardless of the rule set configuration.
* **One Last Time Reporting for Japan**: Configures One Last Time (OLT) reporting logic for reporting to the PMDA for _Transmissions_ in the selected states, regardless of the rule set configuration.
* **Due in Days for Local OLT Submissions**: Specify a number value Vault uses to populate the _Due in Days_ field for all local OLT submissions. This setting appears only after you select a value in the _One Last Time Reporting for Japan_ field.
* **Transmission Reason Determination**: Defines the states of previous _Transmissions_ that Vault considers when determining if a rule engine-created _Transmission_ is _Initial_ or _Follow-Up_.
* **Cross Reporting without Datasheet Expectedness Substitution**: Determines how the Safety reporting rule engine evaluates the _Expected_ rule parameter for cross reporting scenarios where additional _Products_ are found through a _Substance_ lookup.
* **Strict Transmission Version Enforcement**: When enabled, Vault enforces the order in which you are able to send _Transmissions_ via gateway and email to all destinations.
* **Change Localized Case State on Creation**: When enabled, upon _creating a Localized Case_, Vault populates the _Localized Case Creation Method_ field and sets the lifecycle state to the _Ready_ state type.
* **Regenerate Email Transmissions When Submitting to Gateway**: When running the _Submit to Gateway_ action for a _Case_ or _Localized Case_, this setting determines whether Vault regenerates _Transmission_ files (except for _Cover Letters_) before sending the _Transmission_.
* **Use FDA E2B(R3) Transmission Profiles for One Last Time Reporting**: When enabled, Vault matches One Last Time _Submissions_ to the CBER and CDER postmarket and premarket FDA centers for registrations with FDA E2B(R3) transmission profiles.
## Submission and Distribution Settings {#sub-dist}
Note: You should not enable the Use Adverse Event PT on CIOMS and MedWatch 3500A setting if you have enabled the Use Product(Reported) Name on CIOMS and MedWatch 3500A setting in your Vault.
Note: Contact your Veeva representative before enabling these settings in your Vault
Note: In Vaults with strict Case locking enabled, Vault prevents conflicting Case edits in a number of user-initiated scenarios. To learn more, see Manage Strict Case Locking.
Note: Workbench DSUR and PBRER aggregate reports behave as if the following settings are enabled:
Additionally, Workbench DSURs and PBRERs include assessment results, but not Case totals, in SAR Line Listings.